characterization of ferroptosis in murine models of

ACSL4 as the First Reliable Biomarker of Ferroptosis Under

Oct 11, 2019 · Wang H, An P, Xie E et al (2017) Characterization of ferroptosis in murine models of hemochromatosis. Hepatology 66(2):449465 PubMed PubMedCentral CrossRef Google Scholar Wu X, Li Y, Wang J et al (2013) Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer.

Cysteine depletion induces pancreatic tumor ferroptosis in

Apr 03, 2020 · Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is triggered by high intracellular levels of lipid reactive oxygen species. Pancreatic cancer cells have high levels of reactive oxygen species but manage to avoid ferroptosis by Ferroptosis as a novel therapeutic target for

  • Ferroptosis as A Novel Therapeutic Target For Cardiovascular DiseaseAbstractIntroductionMechanisms of FerroptosisFerroptosis and CvdsDiscussionAcknowledgementsReferencesAuthor ContactXiaoguang Wu#, Yi Li#, Shuchen Zhang, Xiang Zhou Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China #These authors contributed equally to this work.Ferroptosis is involved in alcohol-induced cell death in
    • AbstractMaterials and MethodsResultsDiscussionAuthor ContributionsAlcohol is a frequent co-factor in patients with a large range of liver diseases such as hepatitis C virus, alcoholic steatohepatitis, and even hepatocellular carcinoma [1]. Approximately 50% of patients with liver disease is related to immoderate alcohol use [2]. According to the statistics of WHO in 2018, 3 million people die of excessive alcohol intake each year, accounting for 5.3% of global deaths [3]. It is generally known that alcohol is primarily metabolized in liver. Alcohol easily diffuses across the cell membranes Ferroptosis In Liver Diseases EncyclopediaFerroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated

      Ferroptosis as a target for protection against

      Feb 12, 2019 · Nonapoptotic cell death-induced tissue damage has been implicated in a variety of diseases, including neurodegenerative disorder, inflammation, and stroke. In this study, we demonstrate that ferroptosis, a newly defined iron-dependent cell death, mediates both chemotherapy- and ischemia/reperfusion-induced cardiomyopathy. RNA-sequencing analysis revealed up-regulation of Ferroptosis:mechanisms, biology, and role in diseaseThe research field of ferroptosis has been enjoying exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic events, including redox homeostasis, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars, in

      Frontiers Mitochondrial Iron Overload-Mediated

      • IntroductionMethods and MaterialsResultsDiscussionConclusionData Availability StatementAuthor ContributionsFundingConflict of InterestAbbreviationsTraditional Chinese medicine (TCM) has excellent advantages in prevention and treatment of complex and chronic diseases, for instance, chronic kidney disease (CKD) (Wang K-X et al., 2020). For people who suffered from CKD, TCM has been widely used as an effective alternative therapy in China and many Asian countries. In the clinical practice, the classical Chinese herbal formulas, such as Zhenwu Decoction (La et al., 2018) and Dahuang Fuzi Decoction (Tu et al., 2014), have been widely applicated Ferroptosis-related genes for predicting prognosis of Apr 05, 2021 · Previous studies reported that ferroptosis-related genes can regulate the process of tumor cell changes by regulating iron metabolism. However, the prognostic value of ferroptosis-related genes in LC remains to be further elucidated. Ferroptosis-related gene eion profiles of coexisting ferroptosis-related genes were extracted from both cohorts (TCGA and GSE27020) for eligible analysis. Inactivation of the ferroptosis regulator Gpx4 triggers Nov 17, 2014 · Ferroptosis is a form of non-apoptotic cell death with unclear physiological relevance. Conrad and colleagues now report that unrestrained ferroptosis can lead to renal failure.

        Institute of Translational Medicine, Zhejiang University

        Characterization of Ferroptosis in Murine Models of Hemochromatosis. Hepatology. 2017 Aug;66(2):449-465. Epub 2017 May 162017. 23. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J*, Wang F*. HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Iron Accumulation and Lipid Peroxidation in the Aging Sep 16, 2020 · Characterization of ferroptosis in murine models of hemochromatosis. Hepatology, 66:449-465. [202] Kakhlon O, Cabantchik ZI (2002). The labile iron pool:characterization, measurement, and participation in cellular processes(1). Free Radic Biol Med, 33:1037-1046. [203] Cheng Z, Li Y (2007). What is responsible for the initiating chemistry of

        Iron Overload-Induced Ferroptosis Impairs Porcine Oocyte

        Accumulating evidence indicates that ferroptosis is an iron-dependent form of regulated cell death. This type of iron-dependent programmed cell death is different from traditional forms of regulated cell death, such as apoptosis and autophagy. Iron Overload-Induced Ferroptosis Impairs Porcine Oocyte May 28, 2021 · Accumulating evidence indicates that ferroptosis is an iron-dependent form of regulated cell death. This type of iron-dependent programmed cell death is different from traditional forms of regulated cell death, such as apoptosis and autophagy. However, the role of ferroptosis in porcine oocyte maturation and the associated mechanism remain unclear.

        JCI Insight - Necroptosis:a crucial pathogenic mediator

        Aug 08, 2019 · Ferroptosis is an RCD mode that is distinct from necroptosis. In ferroptosis, iron-dependent lipid peroxidation causes lytic cell death, which can be inhibited by glutathione peroxidase 4 (GPX4). The specific role of mtDNA as a necroptosis-related DAMP requires further characterization. In 2 murine models of progressive kidney fibrosis Mechanism of Ferroptosis:A Potential Target for Apr 11, 2020 · Abstract. Ferroptosis is a form of programmed cell death caused by production of reactive oxygen species and disequilibrium of iron homeostasis. Many chemical compounds and clinical drugs induce ferroptosis in normal and cancer cells, while peroxidation inhibitors, iron chelators, and antioxidants can block ferroptosis.

        Nrf2 protects against seawater drowning-induced acute lung

        Sep 09, 2020 · Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe oxidative stress injury, has been a major cause of accidental death worldwide. The latest evidences indicate nuclear factor (erythroid-derived 2)-like 2 (Nrf2) suppress ferroptosis and Phospholipid oxidation products in ferroptotic myocardial Jun 30, 2019 · Ferroptosis is a recently described form of nonapoptotic cell death. It is an iron-mediated form of cell death that occurs because of accumulation of lipid peroxidation products. characterization, measurement, and participation in cellular processes. Free Radic Biol Med 33: Characterization of ferroptosis in murine models of

        Quercetin Alleviates Ferroptosis of Pancreatic Cells in

        (1) Background:Pancreatic iron deposition has been found in the progression of type 2 diabetes (T2DM); however, whether ferroptosis contributes to the dysfunction of pancreatic cells (PBC) remains enigmatic. Moreover, the potential protective effect of quercetin is also elusive; (2) Methods:T2DM mice model was established by multiple low dose streptozocin (STZ) injection, after which Superparamagnetic iron oxide nanoparticles promote Aug 11, 2020 · Ferroptosis is a novel form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxides to lethal levels, which is morphologically, biochemically, and genetically distinct from apoptosis, necroptosis and autophagy. 21 Recent studies found that ferroptosis is not only an important pathological mechanism in the

        (PDF) Characterization of Ferroptosis in Murine Models of

        Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid peroxidation. However, the relationship between