a genetic mouse model of invasive endometrial cancer

A mouse model of endometriosis mimicking the natural

Jan 01, 2020 · In our mouse model, removal of the oviducts and bursal membrane promoted the spread of invasive endometrial cells harboring ARID1A and PIK3CA mutations from the ipsilateral uterine horn. Established mouse models of endometriosis have been limited by the requirement of tissue transplantation, steroid hormone treatment or genetic perturbation in tissues other than the

An orthotopic endometrial cancer mouse model

Aug 19, 2008 · and invasive and metastatic properties are now well established. Although an animal model of endometrial cancer, such as the subcutaneous implantation of endometrial cancer cells in a xeno-graft model, has been used in experimental oncology, there has been no report of an appropriate orthotopic endometrial cancer model. Development of a mouse model for lymph node Development of a mouse model for lymph node metastasis with endometrial cancer Kayoko Takahashi,1,2,4 Yasushi Saga, 2Hiroaki Mizukami,1,3 Yuji Takei, Masashi Urabe, 1Akihiro Kume, Mitsuaki Suzuki2 and Keiya Ozawa1,3 1Division of Genetic Therapeutics, Center for Molecular Medicine, Tochigi; 2Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi,

Endometrial Cancer Early Detection, Diagnosis, and Staging

Stages and Outlook (Prognosis) After a cancer diagnosis, staging provides important information about the amount of cancer in the body, the best treatment options, and the likely response to treatment. Endometrial Cancer Stages. Survival Rates for Endometrial Cancer. Endometrial Tumorigenesis in Pten+/ Mice Is Independent Jun 01, 2012 · Endometrial cancer is the most common malignancy of the female genital tract, and, like most cancers, it is a complex disease comprising a number of different types of carcinoma. Clinicopathologic, epidemiologic, and genetic studies have supported a dualistic model of endometrial carcinoma categorized as type I and type II.

Erbo Xu's research works Dana-Farber Cancer Institute

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition Article Full-text available Evaluating the efficacy of enzalutamide and the In this study, we evaluated the preclinical efficacy of a third-generation AR antagonist, enzalutamide, in a genetic mouse model of EMC, Sprr2f-Cre;Pten fl/fl. In this model, ablation of Pten in the uterine epithelium leads to localized and distant malignant disease as observed in human EMC.

Fbxw7 is a driver of uterine carcinosarcoma by promoting

Dec 17, 2019 · Uterine carcinosarcoma (UCS) is an aggressive endometrial cancer variant distinguished from endometrial adenocarcinoma (EC) by admixed malignant epithelial and mesenchymal components (carcinoma and sarcoma). The molecular events underlying UCS are enigmatic, as cancer gene mutations are generally shared among UCS/EC. We take advantage of genetic approaches in Generation and characterization of orthotopic murine Dec 25, 2011 · We describe the generation of two orthotopic murine models for endometrial cancer (EC).The first model is generated from endometrial Hec-1A cancer cells transfected with luciferase and injected directly into the uterus of female mice. This model allows a follow-up with bioluminescence imaging (BLI) along the experiment and generates abdominal dissemination and lymphatic and

Inactivation of Arid1a in the endometrium is associated

sion of Cre recombinase (Pgr-Cre approach). Non-invasive endometrial cancer was observed in this genetically engineered mouse model, supporting a key role(s) of PTEN in endometrial pathogenesis17. However, progesterone receptor is also eed in stromal JCI - LKB1 loss promotes endometrial cancer progression Sep 28, 2015 · We previously developed a mouse model of uterine cancer based on conditional inactivation of LKB1 in the endometrial epithelium. One of the remarkable properties of this model is that inactivation of a single tumor suppressor LKB1 is sufficient to give rise to endometrial adenocarcinomas with complete penetrance and short latency.

Lkb1 inactivation is sufficient to drive endometrial

In contrast to our earlier mouse model of Lkb1-deficient endometrial cancer, which was based on postnatal gene inactivation through intrauterine injection of Ad-Cre (Contreras et al., 2008a),3 Sprr2f-Cre; Lkb1 L/L females developed highly invasive adenocarcinomas by only 12 weeks of age. These invasive cancers progressed in a highly Metformin suppresses cancer initiation and progression in Jul 24, 2017 · The development of genetically engineered mouse models has led to an understanding of the initiation and progression of pancreatic cancer, thus providing a more efficient tool for the research of pancreatic cancer prevention and treatment . Oncogenic Kras-mediated PDAC mouse models recapitulate tumor onset and progression from ADM to mPanINs and eventually to invasive pancreatic cancer.

Oviduct-specific glycoprotein is a molecular marker for

Mar 15, 2009 · Oviduct-specific glycoprotein is a molecular marker for invasion in endometrial tumorigenesis identified using a relevant mouse model. Wang H(1), Joshi A, Iaconis L, Solomon GJ, Xiang Z, Verhage HG, Douglas W, Ronnett BM, Ellenson LH. PTEN deficiency sensitizes endometrioid endometrial cancer Sep 25, 2017 · The combination of BKM120 and Olaparib cooperated to inhibit tumor growth in a genetic mouse model of Pten-deficient endometrioid endometrial cancer. A genetic mouse model of invasive

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

  • PTEN ModelsPI3K ModelsAkt ModelsFuture DirectionsIn the 1990s, gene knock-out studies demonstrated that PTEN acts as a tumor suppressor (6770). PTEN homozygous knock-out mice are embryonic lethal, but heterozygous PTEN+/ mice demonstrate many of the features described in human cancer hereditary syndromes with defective PTEN. These mice develop tumors in multiple tissues, including breast tissue, the endometrium, and prostate, which is similar to the cancer predisposition pattern in human Cowden syndrome (6770). Tissue-specific PTEWhat Is Endometrial Cancer?Types of endometrial cancer. Endometrial cancer (also called endometrial carcinoma) starts in the cells of the inner lining of the uterus (the endometrium). This is the most common type of cancer in the uterus. Endometrial carcinomas can be divided into different A genetic mouse model of invasive endometrial cancer A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Academic Article Overview abstract . Signals from the tumor suppressors PTEN and LKB1 converge on mTOR to negatively regulate its function in cancer cells.